Article last updated: October 15, 2024
Rh-Polypeptide-59 is a fascinating ingredient in the world of cosmetics, known for its skin conditioning and skin protecting properties. This single chain recombinant human peptide is produced through a sophisticated fermentation process involving E. coli bacteria. The starting gene for Rh-Polypeptide-59 is directly isolated from a human cell, specifically coding for the Platelet Derived Growth Factor Beta Polypeptide. This gene is either used in its original form or adapted to suit the production host, ensuring the peptide’s efficacy and safety.
Chemically, Rh-Polypeptide-59 is composed of a maximum of 109 amino acids, which may include disulfide bonds and glycosylation. These amino acids are the building blocks of proteins and are arranged in a sequence that mimics the natural human peptide. The protein consists of the proper sequence of the 20 standard amino acids, making it a biotechnologically advanced ingredient.
The journey of Rh-Polypeptide-59 into the cosmetic industry is rooted in its origins in medical and biological research. Initially studied for its role in cell growth and tissue repair, scientists soon recognized its potential for skin care applications. The ability of Rh-Polypeptide-59 to promote skin health and protection made it an attractive candidate for inclusion in various cosmetic formulations.
The production of Rh-Polypeptide-59 involves a meticulous process. It starts with the isolation of the gene from human cells, which is then inserted into E. coli bacteria. These bacteria act as tiny factories, fermenting and producing the peptide in large quantities. Once the fermentation process is complete, the peptide is extracted, purified, and prepared for use in cosmetic products. This method ensures that the peptide is produced consistently and safely, adhering to high standards of quality and efficacy.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Rh-Polypeptide-59:
Rh-Polypeptide-59 is known for its skin conditioning properties. This means it helps to maintain the skin in good condition by improving its appearance and texture. When applied in cosmetic formulations, it can make the skin feel softer, smoother, and more hydrated. Essentially, it helps to keep your skin looking and feeling its best, which is why it’s a popular ingredient in many skincare products.
Another significant benefit of Rh-Polypeptide-59 is its skin protecting function. This ingredient helps to shield the skin from various environmental stressors, such as pollution and harsh weather conditions. By forming a protective barrier on the skin’s surface, it can help to prevent damage and maintain the skin’s integrity. This makes it a valuable addition to products aimed at preserving skin health and preventing premature aging.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Rh-Polypeptide-59 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Rh-Polypeptide-59 during pregnancy are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
While adverse reactions to Rh-Polypeptide-59 are relatively uncommon, it is always recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
On the comedogenicity scale, Rh-Polypeptide-59 is rated as 0, meaning it is considered non-comedogenic. This makes it suitable for individuals prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
