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Ovatodiolide: An In-Depth Look at Its Role in Cosmetics

Article last updated: June 13, 2024

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Ever wondered what makes your favorite skincare products so effective? Dive into the world of Ovatodiolide and discover its transformative role in cosmetics, from its creation to its myriad benefits and potential side effects.

What Is Ovatodiolide?

Ovatodiolide, also known by its chemical name (3E,12E)-3,12-Dimethyl-8-methylene-6,18-dioxa-tricyclo(,9)nonadeca-3,12,16(19)-triene-7,17-dione, is a naturally occurring compound that has garnered attention in the cosmetic industry for its impressive properties. This compound is primarily derived from the plant Anisomeles indica, commonly known as catmint or Indian nettle, which has been used in traditional medicine for centuries.

The history of ovatodiolide in cosmetics is relatively recent. Initially, it was studied for its medicinal properties, particularly in traditional Asian medicine where it was used for its antimicrobial and anti-inflammatory effects. As research progressed, scientists discovered that ovatodiolide also possessed significant antioxidant and skin conditioning properties, making it a valuable ingredient in skincare formulations.

The production of ovatodiolide typically involves the extraction of the compound from the leaves and stems of Anisomeles indica. This process often includes solvent extraction followed by purification steps to isolate the ovatodiolide in its pure form. The resulting compound is then incorporated into various cosmetic products, ranging from creams and serums to lotions and masks, to leverage its beneficial properties for skin health.

The Benefits/Uses of Ovatodiolide

In this section, we will delve into the officially recognized cosmetic benefits and uses of Ovatodiolide:


Ovatodiolide is recognized for its antimicrobial properties. This means it can help in preventing the growth of bacteria, fungi, and other microorganisms on the skin. In practical terms, this can be particularly beneficial in products aimed at acne-prone skin, as it helps to keep the skin clean and reduce the likelihood of breakouts caused by bacterial infections.


Another significant benefit of Ovatodiolide is its antioxidant capability. Antioxidants are crucial in protecting the skin from damage caused by free radicals, which are unstable molecules that can cause premature aging and other skin issues. By neutralizing these free radicals, Ovatodiolide helps to maintain the skin’s youthful appearance and overall health.

Skin Conditioning

Ovatodiolide also serves as a skin conditioning agent. This means it helps to keep the skin in good condition by improving its texture and appearance. It can make the skin feel softer and smoother, and it may also help in maintaining the skin’s moisture balance, making it a valuable ingredient in moisturizers and other skincare products aimed at enhancing skin feel and look.

Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Ovatodiolide is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects that users should be aware of:

  • Skin irritation
  • Redness
  • Allergic reactions

Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Ovatodiolide during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.

Side effects and adverse reactions from Ovatodiolide are relatively uncommon, but they can occur. It is recommended to perform a patch test before widespread usage to ensure that your skin does not react negatively to the ingredient.

Ovatodiolide has a comedogenic rating of 1, which means it is very unlikely to clog pores. This makes it a suitable option for individuals who are prone to acne, blemishes, or breakouts.

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