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Octahydro-Tetramethyl-Methanoazulene: An In-Depth Look at Its Role in Cosmetics

Article last updated: June 13, 2024

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Ever wondered what gives your favorite skincare products their magical touch? Dive into the world of Octahydro-Tetramethyl-Methanoazulene and discover its transformative role in cosmetics, from its creation to its incredible benefits and potential side effects.

What is Octahydro-Tetramethyl-Methanoazulene?

Octahydro-Tetramethyl-Methanoazulene, also known by its chemical name (1S-(1a,4a,7a))-1,2,3,4,5,6,7,8-Octahydro-1,4,9,9-tetramethyl-4,7-methanoazulene, is a synthetic compound primarily used in the cosmetic industry for its perfuming properties. This ingredient is often derived from a complex chemical synthesis process involving multiple steps to achieve its final structure. It is also sometimes referred to by other names in the industry, such as Iso E Super, which is a popular fragrance ingredient in many high-end perfumes.

The history of Octahydro-Tetramethyl-Methanoazulene in cosmetics dates back to the mid-20th century when chemists were exploring new synthetic routes to create unique and long-lasting fragrance molecules. Its introduction revolutionized the perfuming industry by providing a stable and versatile scent component that could be used in a wide range of products, from perfumes to lotions and creams.

The production of Octahydro-Tetramethyl-Methanoazulene involves a series of chemical reactions, typically starting with the hydrogenation of certain precursor molecules. This is followed by methylation and cyclization steps to form the characteristic azulene structure. The process requires precise control of reaction conditions to ensure the purity and consistency of the final product, making it a sophisticated and carefully monitored manufacturing endeavor.

The Benefits/Uses of Octahydro-Tetramethyl-Methanoazulene

In this section, we will delve into the officially recognized cosmetic benefits and uses of Octahydro-Tetramethyl-Methanoazulene:


Octahydro-Tetramethyl-Methanoazulene is primarily used in cosmetics for its perfuming properties. This means it is added to products to impart a pleasant fragrance. When you apply a cosmetic product containing this ingredient, it helps to mask any unpleasant odors that might be present in the formulation, making the overall experience of using the product more enjoyable. Essentially, it enhances the sensory appeal of the product, making it smell good and feel luxurious.

Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Octahydro-Tetramethyl-Methanoazulene is generally considered safe for use in cosmetic products, primarily serving as a perfuming agent. However, like any ingredient, it may not be suitable for everyone and can potentially cause side effects.

  • Skin irritation
  • Allergic reactions
  • Contact dermatitis

Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Octahydro-Tetramethyl-Methanoazulene during pregnancy are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice.

Side effects and adverse reactions from this ingredient are generally uncommon, but they can occur. It is recommended to conduct a patch test before widespread usage to ensure there are no adverse reactions.

On the comedogenicity scale, Octahydro-Tetramethyl-Methanoazulene is rated at 1, meaning it has a low potential to clog pores. This makes it relatively safe for individuals who are prone to acne, blemishes, or breakouts, although individual reactions can vary.

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