Article last updated: October 15, 2024
Nobiletin, also known by its chemical name 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, is a naturally occurring polymethoxylated flavone. It is often referred to by other names such as 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy, and 3′,4′,5,6,7,8-hexamethoxyflavone. This compound is primarily sourced from citrus peels, particularly those of oranges and tangerines.
Historically, nobiletin has been studied for its various health benefits, including anti-inflammatory and anti-cancer properties. Its journey into the cosmetic industry began when researchers discovered its potent antioxidant and antimicrobial activities, making it a valuable ingredient for skincare formulations. These properties help in protecting the skin from oxidative stress and microbial contamination, which are common concerns in cosmetic products.
Nobiletin is typically extracted from citrus peels through a process involving solvent extraction and purification. The citrus peels are first dried and ground into a powder, which is then subjected to solvents like ethanol or methanol to extract the nobiletin. The extract is further purified using techniques such as chromatography to isolate nobiletin in its pure form. This purified compound is then incorporated into various cosmetic formulations, offering a range of benefits from preservation to skin protection.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nobiletin:
Nobiletin is known for its antimicrobial properties, which means it can help inhibit the growth of bacteria, fungi, and other microorganisms on the skin. This is particularly beneficial in cosmetic products as it helps to keep the skin clean and reduce the risk of infections. For example, in a facial cleanser or a body wash, Nobiletin can help ensure that your skin remains free from harmful microbes that can cause acne or other skin issues.
Another significant benefit of Nobiletin is its antioxidant capability. Antioxidants are crucial in protecting the skin from damage caused by free radicals, which are unstable molecules that can cause premature aging and other skin problems. By incorporating Nobiletin into skincare products like serums or moisturizers, you can help protect your skin from environmental stressors such as pollution and UV radiation, thereby maintaining a youthful and healthy appearance.
Nobiletin also functions as a preservative in cosmetic formulations. This means it helps to extend the shelf life of products by preventing the growth of microorganisms that can spoil the product. When used in creams, lotions, or other skincare items, Nobiletin ensures that the product remains effective and safe to use over a longer period, providing you with more value for your money.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nobiletin is generally considered safe for topical use in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of nobiletin during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from nobiletin are generally uncommon. However, as with any new skincare product, it is recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, nobiletin has a rating of 1 on a scale of 0 (totally non-comedogenic) to 5 (highly comedogenic). This low rating means it is unlikely to clog pores, making it suitable for individuals prone to acne, blemishes, or breakouts.
