Article last updated: October 15, 2024
Nicotiana Benthamiana Sh-Polipedtide-45, also known as a single chain recombinant human peptide, is a fascinating ingredient in the world of cosmetics. This peptide is produced by the plant Nicotiana benthamiana, a relative of the tobacco plant, through advanced biotechnological methods. The production involves either a transient expression system or transgenesis, which is the stable insertion of a copy of a human gene into the plant’s DNA. The gene used is synthesized to be identical to the human gene that codes for Granulocyte Macrophage Colony Stimulating Factor (GM-CSF).
Chemically, Nicotiana Benthamiana Sh-Polipedtide-45 is composed of up to 144 amino acids, which may include disulfide bonds and glycosylation. These amino acids are the building blocks of proteins and are arranged in a sequence that mirrors the 20 standard amino acids found in the human body.
The journey of this peptide into the cosmetic industry is quite intriguing. Initially, the focus was on its medical applications, given its origin from GM-CSF, a protein involved in immune responses. However, researchers soon discovered its potential benefits for skin conditioning, leading to its adoption in skincare products. The process of making this peptide involves sophisticated genetic engineering techniques where the desired human gene is inserted into Nicotiana benthamiana. The plant then produces the peptide, which is subsequently harvested and purified for use in cosmetics.
This innovative approach not only ensures a high degree of similarity to human peptides but also allows for sustainable and scalable production, making it a valuable addition to modern skincare formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Sh-Polipedtide-45:
Nicotiana Benthamiana Sh-Polipedtide-45 is primarily recognized for its skin conditioning properties. This means it helps to maintain the skin in good condition, making it feel smoother, softer, and more supple. When applied in cosmetic formulations, this ingredient can enhance the overall texture and appearance of the skin, providing a more youthful and radiant look. It works by supporting the skin’s natural functions, ensuring it remains hydrated and balanced.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Sh-Polypedtide-45 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects that users should be aware of:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Sh-Polypedtide-45 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Nicotiana Benthamiana Sh-Polypedtide-45 are generally uncommon. However, it is always a good practice to perform a patch test before widespread usage to ensure that your skin does not react negatively to the ingredient.
In terms of comedogenicity, Nicotiana Benthamiana Sh-Polypedtide-45 is rated as a 0 on a scale of 0 to 5, meaning it is considered non-comedogenic. This makes it suitable for individuals who are prone to acne, blemishes, or breakouts, as it is unlikely to clog pores.
