Article last updated: October 15, 2024
Nicotiana Benthamiana R-(S-Spider Polypeptide-6 Tripeptide-44 Sh-Polypeptide-121), often referred to by its more manageable nicknames like “Spider Peptide Complex” or “Nicotiana Peptide Blend,” is a cutting-edge cosmetic ingredient derived from the Nicotiana benthamiana plant. This peptide is a single chain recombinant peptide, meaning it is produced through genetic engineering techniques. Specifically, the Nicotiana benthamiana plant is transformed using either a transient expression system or through stable transgenesis, where a synthetic gene is inserted into the plant’s DNA. The starting gene itself is a fusion of three distinct genes: s-Spider Polypeptide-6, Tripeptide-44, and sh-Polypeptide-121, resulting in a complex peptide that can contain up to 1017 amino acids, complete with potential disulfide bonds and glycosylation.
The journey of this peptide into the world of cosmetics is a fascinating one. Initially, the fusion of these genes was aimed at harnessing the unique properties of each component—spider silk’s strength and elasticity, Tripeptide-44’s skin conditioning benefits, and sh-Polypeptide-121’s protective qualities. Through advanced biotechnological methods, scientists were able to synthesize this peptide, opening up new possibilities for skincare formulations. The use of Nicotiana benthamiana as a bio-factory for this peptide is particularly innovative, as it allows for scalable and sustainable production.
In terms of its chemical composition, the fusion peptide is made up of the 20 standard amino acids arranged in a specific sequence to maximize its efficacy. The presence of disulfide bonds and glycosylation can further enhance its stability and functionality on the skin. This intricate structure is what enables the peptide to perform its official functions as listed in the CosIng Database: film forming, skin conditioning, and skin protecting.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana R-(S-Spider Polypeptide-6 Tripeptide-44 Sh-Polypeptide-121):
This ingredient has the ability to form a thin, continuous film on the surface of the skin. What does this mean for you? Essentially, it can create a protective barrier that helps to lock in moisture and shield your skin from environmental aggressors like pollution and harsh weather. This film-forming property can also give your skin a smoother appearance, making it a popular choice in products aimed at providing a flawless finish.
Nicotiana Benthamiana R-(S-Spider Polypeptide-6 Tripeptide-44 Sh-Polypeptide-121) is recognized for its skin conditioning properties. This means it can help to maintain the skin’s softness, suppleness, and overall health. By improving the texture and feel of your skin, it can make your complexion look more radiant and youthful. This is particularly beneficial in moisturizers, serums, and other skincare products designed to enhance skin quality.
Another key benefit of this ingredient is its skin protecting function. It helps to defend your skin against potential damage from external factors such as UV radiation, pollutants, and other environmental stressors. By incorporating this ingredient into your skincare routine, you can help to fortify your skin’s natural defenses, keeping it healthier and more resilient over time.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana R-(S-Spider Polypeptide-6 Tripeptide-44 Sh-Polypeptide-121) is generally considered safe for topical application, but as with any cosmetic ingredient, it is important to be aware of potential side effects and other considerations.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana R-(S-Spider Polypeptide-6 Tripeptide-44 Sh-Polypeptide-121) during pregnancy are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice.
Adverse reactions to this ingredient are relatively uncommon, but they can occur. To minimize the risk of an adverse reaction, it is recommended to perform a patch test before widespread usage.
In terms of comedogenicity, Nicotiana Benthamiana R-(S-Spider Polypeptide-6 Tripeptide-44 Sh-Polypeptide-121) has a comedogenic rating of 1, which means it is unlikely to clog pores and is generally suitable for people prone to acne, blemishes, or breakouts.
