Article last updated: October 15, 2024
Nicotiana Benthamiana R-(S-Solitary Bee Oligopeptide-1 Pentapeptide-75 S-Propionibacterium Phage P9.1 Polypeptide-1), often referred to by its more manageable nickname, NB-RSPP, is a fascinating and complex ingredient making waves in the cosmetic industry. This single-chain recombinant peptide is derived from the Nicotiana benthamiana plant, a relative of the tobacco plant, through advanced biotechnological methods. The peptide is produced after the plant undergoes transformation via either a transient expression system or transgenesis, which involves the stable insertion of a synthetic gene into its DNA.
The creation of NB-RSPP is a marvel of modern science. It begins with the synthesis of a gene that fuses elements from three distinct sources: S-Solitary Bee Oligopeptide-1, Pentapeptide-75, and S-Propionibacterium Phage P9.1 Polypeptide-1. This fusion results in a peptide composed of 317 amino acids, which may include disulfide bonds and glycosylation, ensuring the proper sequence of the 20 standard amino acids. The intricate process of synthesizing and expressing this peptide in Nicotiana benthamiana plants allows for the production of a highly specialized ingredient with unique properties.
The journey of NB-RSPP into the realm of cosmetics is relatively recent but significant. Initially explored for its potential in medical and pharmaceutical applications, researchers soon recognized its benefits for skin care. Its antimicrobial, lytic, and skin-protecting properties, as listed in the CosIng Database, make it a valuable addition to various cosmetic formulations. This peptide’s ability to protect and enhance the skin has led to its inclusion in a range of products, from creams to serums, aimed at improving skin health and appearance.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana R-(S-Solitary Bee Oligopeptide-1 Pentapeptide-75 S-Propionibacterium Phage P9.1 Polypeptide-1):
This ingredient has antimicrobial properties, which means it can help to inhibit the growth of microorganisms on the skin. In practical terms, this can be particularly beneficial in skincare products aimed at reducing acne or preventing infections. By keeping harmful bacteria at bay, it helps maintain a healthier skin environment, reducing the likelihood of breakouts and other skin issues caused by microbial activity.
The lytic function of this peptide means it can break down cell walls of certain bacteria. This is especially useful in targeting and eliminating unwanted bacteria on the skin. For those struggling with acne or other bacterial skin conditions, this ingredient can help to clear up the skin by effectively breaking down and removing the bacteria responsible for these issues.
As a skin-protecting agent, Nicotiana Benthamiana R-(S-Solitary Bee Oligopeptide-1 Pentapeptide-75 S-Propionibacterium Phage P9.1 Polypeptide-1) helps to shield the skin from environmental stressors. This can include protection against pollutants, UV radiation, and other external factors that can cause skin damage. By forming a protective barrier, it helps to maintain the skin’s integrity and overall health, making it a valuable addition to daily skincare routines.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
When considering the use of Nicotiana Benthamiana R-(S-Solitary Bee Oligopeptide-1 Pentapeptide-75 S-Propionibacterium Phage P9.1 Polypeptide-1) in cosmetic products, it is important to be aware of its safety, suitability, and allergenic potential.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of this particular ingredient during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to this ingredient are generally uncommon, but as with any cosmetic ingredient, individual responses can vary. It is recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Nicotiana Benthamiana R-(S-Solitary Bee Oligopeptide-1 Pentapeptide-75 S-Propionibacterium Phage P9.1 Polypeptide-1) is rated as a 1 on a scale of 0 (totally non-comedogenic) to 5 (highly comedogenic). This low rating suggests that it is unlikely to clog pores and is generally suitable for individuals prone to acne, blemishes, or breakouts.
