Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86, sometimes referred to as NBH-40 Sh-Polypeptide-86, is a unique fusion peptide used in the cosmetic industry, particularly for hair conditioning. This ingredient is derived from the Nicotiana benthamiana plant, a relative of the tobacco plant, which has been genetically modified to produce a specific human peptide. The human gene used in this process is identical to the one that codes for Follistatin, a protein known for its role in muscle growth and regeneration, and it contains up to 344 amino acids.
The history of NBH-40 Sh-Polypeptide-86 in cosmetics is relatively recent, emerging from advancements in biotechnology and genetic engineering. Scientists discovered that by inserting a copy of the human gene into the DNA of Nicotiana benthamiana, they could produce a recombinant human peptide in the plant. This process involves either transient expression, where the gene is temporarily introduced, or stable insertion, where the gene becomes a permanent part of the plant’s genome.
The production of this fusion peptide is a fascinating blend of plant biology and genetic engineering. Initially, the human gene is synthesized to match the Follistatin gene. This gene is then introduced into Nicotiana benthamiana plants, which are cultivated under controlled conditions. The plants express the gene, producing the desired peptide, which is then harvested and purified for use in cosmetic formulations. The resulting fusion peptide, containing 294 amino acids, may include disulfide bonds and glycosylation, ensuring it maintains the proper sequence and structure of the 20 standard amino acids.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86 is primarily known for its hair conditioning properties. This means that when included in hair care products, it helps to improve the texture and appearance of your hair. It works by coating the hair strands, making them smoother and easier to manage. This can lead to reduced frizz, enhanced shine, and an overall healthier look and feel to your hair. Essentially, it helps to keep your hair looking its best by maintaining its moisture balance and protecting it from environmental damage.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects to be aware of:
Regarding individuals who are pregnant or breastfeeding, there is currently a lack of data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86 during pregnancy and breastfeeding. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from this ingredient are generally uncommon. However, it is always recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-86 has a comedogenic rating of 1, which means it is very unlikely to clog pores. This makes it suitable for individuals who are prone to acne, blemishes, or breakouts.
