Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76, often referred to simply as Hexapeptide-40, is a fusion peptide that combines Hexapeptide-40 with a single chain recombinant human peptide. This unique ingredient is produced using Nicotiana benthamiana, a plant species known for its ability to express complex proteins. The human gene used in this process is synthesized to be identical to the gene coding for Transforming Growth Factor Beta-2 (TGF-β2), a protein involved in various cellular processes including cell growth and differentiation.
The journey of Hexapeptide-40 into the world of cosmetics is quite fascinating. Initially, Nicotiana benthamiana was primarily utilized in the pharmaceutical industry for the production of vaccines and therapeutic proteins. However, its potential in the cosmetic industry was soon recognized due to its ability to produce high-quality, bioactive peptides. This led to the development of Hexapeptide-40, which leverages the plant’s protein expression capabilities to create a peptide that mimics human proteins.
The production process of Hexapeptide-40 involves the genetic engineering of Nicotiana benthamiana plants. Scientists insert the synthesized human gene coding for TGF-β2 into the plant’s genome. The plant then expresses this gene, producing the desired peptide. The peptide is subsequently extracted and purified for use in cosmetic formulations. This innovative approach not only ensures the bioactivity of the peptide but also offers a sustainable and scalable method of production.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. When applied in cosmetic formulations, it can enhance the appearance and feel of the skin, making it softer, smoother, and more supple. Essentially, it works to improve the overall texture and hydration of the skin, giving it a healthier and more youthful look.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is generally considered safe for topical application in cosmetic products. However, as with any skincare ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from this ingredient are generally uncommon. However, it is always recommended to perform a patch test before widespread usage to ensure that your skin does not react adversely to the ingredient.
On a comedogenicity scale of 0 to 5, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 is rated as 0, meaning it is non-comedogenic. This indicates that it is unlikely to clog pores, making it suitable for individuals who are prone to acne, blemishes, or breakouts.
