Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 is a unique fusion peptide that has been making waves in the cosmetic industry. This ingredient is derived from the plant Nicotiana benthamiana, a relative of the tobacco plant, which is genetically modified to produce a specific human peptide. The human gene used in this process is synthesized to be identical to the one that codes for Transforming Growth Factor Beta-3 (TGF-β3), a protein known for its role in skin regeneration and repair.
The journey of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 into the world of cosmetics is quite fascinating. Initially, the use of plants like Nicotiana benthamiana in biotechnology was primarily focused on pharmaceutical applications. However, the potential for these plants to produce complex human proteins led to their exploration in the cosmetic field. By transiently expressing or stably inserting the human gene into the plant’s DNA, scientists can harness the plant’s machinery to produce the desired peptide.
The production process involves the insertion of a synthesized human gene into the DNA of Nicotiana benthamiana. This gene codes for TGF-β3, which can contain up to 412 amino acids and may include disulfide bonds and glycosylation. The plant then produces the protein, which is harvested and purified for use in cosmetic formulations. The resulting peptide consists of the proper sequence of the 20 standard amino acids, ensuring its compatibility and effectiveness in skin conditioning applications.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. In practical terms, this ingredient can help improve the overall appearance and feel of your skin. It works by enhancing the skin’s natural barrier, making it more resilient to environmental stressors and reducing the appearance of dryness and flakiness. This can result in smoother, softer, and more hydrated skin, giving you a healthier and more youthful complexion.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 is generally considered safe for topical application, but like any cosmetic ingredient, it may not be suitable for everyone. Its allergenic potential is relatively low, but individual reactions can vary.
Possible side effects of topical application of this ingredient include:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 during pregnancy and breastfeeding are lacking. Therefore, it is advisable to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to this ingredient are uncommon, but it is always recommended to perform a patch test before widespread usage to ensure there is no adverse reaction.
The comedogenicity of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-5 is rated at 1 on a scale of 0 to 5, where 0 is totally non-comedogenic and 5 is highly comedogenic. This low rating means it is unlikely to clog pores and is generally suitable for people prone to acne, blemishes, or breakouts.
