Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-133 Tetrapeptide-78 is a mouthful, but it’s essentially a fusion peptide derived from the Nicotiana benthamiana plant. This ingredient is also known by its more technical name, which reflects its complex structure: a combination of Hexapeptide-40, Sh-Polypeptide-133, and Tetrapeptide-78. Chemically, it consists of 1132 amino acids and may feature disulfide bonds and glycosylation, which are modifications that can affect its stability and function.
The journey of this peptide into the world of cosmetics is quite fascinating. Initially, Nicotiana benthamiana, a relative of the tobacco plant, was primarily used in scientific research due to its susceptibility to viral infections, making it an excellent model for studying plant-pathogen interactions. However, with advancements in biotechnology, scientists discovered that this plant could be genetically modified to produce complex proteins, including human-like peptides. By using either transient expression systems or stable transgenesis, researchers were able to insert human genes into the plant’s DNA, leading to the production of this unique fusion peptide.
The production process involves transforming Nicotiana benthamiana with specific genetic sequences that encode for Hexapeptide-40, Sh-Polypeptide-133, and Tetrapeptide-78. Once the plant expresses these peptides, they are harvested and purified to create the final cosmetic ingredient. This biotechnological approach not only ensures a high degree of purity but also allows for the large-scale production of these peptides, making them accessible for use in various skincare products.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-133 Tetrapeptide-78:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-133 Tetrapeptide-78 is known for its skin conditioning properties. This means it helps to maintain the skin in good condition by improving its overall appearance and feel. In simpler terms, it can make your skin look smoother, softer, and more hydrated. Think of it as a moisturizer on steroids, working to keep your skin looking its best.
This ingredient also has skin protecting capabilities. It helps to shield the skin from environmental stressors like pollution, UV rays, and harsh weather conditions. By forming a protective barrier, it minimizes potential damage and helps maintain the skin’s natural resilience. Essentially, it acts like a protective shield, ensuring your skin stays healthy and less prone to damage from external factors.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-133 Tetrapeptide-78 during pregnancy and breastfeeding are lacking. Therefore, it is recommended that they consult a healthcare professional for further advice.
While Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-133 Tetrapeptide-78 is generally considered safe for topical application, there are potential side effects to be aware of:
Adverse reactions to this ingredient are relatively uncommon, but it is always prudent to conduct a patch test before widespread usage to ensure personal tolerance.
On a comedogenicity scale of 0 to 5, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-133 Tetrapeptide-78 is rated as a 1, indicating that it is minimally comedogenic. This means it is unlikely to clog pores and cause acne or breakouts, making it suitable for individuals prone to blemishes.
