Article last updated: October 15, 2024
Niacinamide Riboside Chloride, also known by its chemical name Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl-, chloride (1:1), is a derivative of Vitamin B3 (niacin). In the world of cosmetics, it’s often referred to simply as Niacinamide Riboside or NR. This ingredient has garnered attention for its potent antioxidant and skin-protecting properties, making it a valuable addition to skincare formulations.
The journey of Niacinamide Riboside Chloride into the realm of cosmetics is quite fascinating. Initially, it was studied for its potential health benefits, particularly in the context of cellular energy production and anti-aging. Researchers discovered that NR could be converted into nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular metabolism. This discovery opened the door to its application in skincare, where maintaining cellular health is key to youthful, resilient skin.
Niacinamide Riboside Chloride is synthesized through a series of chemical reactions that involve the ribosylation of niacinamide. This process essentially attaches a ribose sugar molecule to niacinamide, resulting in a compound that is more stable and bioavailable. The chloride part of the name indicates that the compound is in its chloride salt form, which enhances its solubility and stability in cosmetic formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Niacinamide Riboside Chloride:
Niacinamide Riboside Chloride acts as an antioxidant, which means it helps to neutralize free radicals in the skin. Free radicals are unstable molecules that can cause damage to your skin cells, leading to premature aging, dullness, and other skin issues. By incorporating this ingredient into your skincare routine, you can help protect your skin from environmental stressors like pollution and UV radiation, which are known to generate free radicals. This protection can result in a more youthful and radiant complexion.
Another significant benefit of Niacinamide Riboside Chloride is its skin-protecting properties. This ingredient helps to strengthen the skin’s natural barrier, making it more resilient against external aggressors. A robust skin barrier is essential for maintaining hydration and preventing irritants from penetrating the skin. This can be particularly beneficial for individuals with sensitive or compromised skin, as it helps to reduce redness, irritation, and overall skin sensitivity.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Niacinamide Riboside Chloride is generally considered safe for topical application, but like any cosmetic ingredient, it may not be suitable for everyone. It is important to be aware of its potential side effects and other considerations before incorporating it into your skincare routine.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Niacinamide Riboside Chloride during pregnancy are lacking. Therefore, it is advisable for pregnant or breastfeeding women to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to Niacinamide Riboside Chloride are relatively uncommon, but they can occur. To minimize the risk of experiencing any side effects, it is recommended to perform a patch test before widespread usage.
On the comedogenicity scale, Niacinamide Riboside Chloride is rated as 0, meaning it is non-comedogenic. This makes it a suitable option for individuals prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
