Article last updated: October 15, 2024
Hyaluronidase is an enzyme that plays a crucial role in the breakdown of hyaluronic acid, a naturally occurring substance in the skin that helps maintain moisture and elasticity. In the cosmetic world, hyaluronidase is often referred to by other names such as “hyaluronoglucosaminidase” or simply “HYAL.” Its primary function, as recognized by the CosIng Database, is skin conditioning, making it a valuable ingredient in various skincare formulations.
The history of hyaluronidase in cosmetics dates back to its initial discovery in the early 20th century when scientists first identified its ability to hydrolyze hyaluronic acid. Initially, it was used in medical settings to enhance the absorption and dispersion of other injected drugs. Over time, its potential benefits for skin conditioning were recognized, leading to its incorporation into cosmetic products aimed at improving skin texture and hydration.
Hyaluronidase is typically derived from animal sources, such as bovine or ovine testicular tissue, although recombinant DNA technology has also enabled the production of human-compatible versions of the enzyme. The manufacturing process involves isolating the enzyme from these sources and purifying it to ensure its efficacy and safety for use in skincare products. This meticulous process ensures that the hyaluronidase used in cosmetics is of high quality and suitable for topical application.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Hyaluronidase:
Hyaluronidase is primarily recognized for its skin conditioning properties. This means that it helps to maintain the skin in good condition, making it feel softer, smoother, and more hydrated. By breaking down hyaluronic acid, which is a natural substance in the skin that holds water, Hyaluronidase can help to manage the levels of this acid, ensuring that the skin does not become overly saturated or dehydrated. This balance is crucial for maintaining a healthy and youthful appearance.
Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
When considering the use of hyaluronidase in cosmetic products, it is important to be aware of its safety, suitability, and allergenic potential. While generally considered safe for topical application, some individuals may experience side effects. These can include:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of hyaluronidase during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to hyaluronidase are relatively uncommon, but it is still recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, hyaluronidase has a rating of 0, meaning it is considered non-comedogenic. This is beneficial for individuals prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
