Article last updated: October 15, 2024
Human Keratinocyte Conditioned Media (HKCM) is a fascinating ingredient in the world of cosmetics, often touted for its skin-conditioning properties. Essentially, it is the growth media removed from cultures of human keratinocytes after several days of growth. Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. The starting media for this process is typically Dulbecco’s Modified Eagle Medium (DMEM), which may or may not contain fetal bovine serum.
HKCM is sometimes referred to by other names, such as Human Keratinocyte Extract or simply Keratinocyte Conditioned Media. Its chemical composition can vary but generally includes a mix of proteins, growth factors, and cytokines that are secreted by the keratinocytes during their growth phase. These components are believed to contribute to its skin-conditioning effects.
The history of HKCM in cosmetics is relatively recent but rooted in scientific research. Initially, keratinocyte cultures were primarily used in medical and dermatological research to study skin diseases and wound healing. Over time, scientists discovered that the conditioned media from these cultures had beneficial properties for skin care, leading to its incorporation into cosmetic products.
The production of HKCM involves cultivating human keratinocytes in a controlled laboratory environment. These cells are grown in DMEM, and after several days, the media is collected. This media is then filtered and processed to ensure it is free from contaminants before being added to cosmetic formulations. The result is a potent ingredient that aims to improve skin texture, hydration, and overall appearance.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Human Keratinocyte Conditioned Media:
Human Keratinocyte Conditioned Media is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. In practical terms, this can translate to a smoother, more hydrated, and overall healthier-looking complexion. The media contains a variety of growth factors and proteins that can support the skin’s natural repair processes, making it a popular ingredient in anti-aging and rejuvenating skincare products.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Human Keratinocyte Conditioned Media is generally considered safe for topical use in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Human Keratinocyte Conditioned Media during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from this ingredient are relatively uncommon. However, it is always recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
Human Keratinocyte Conditioned Media has a comedogenic rating of 1, meaning it is very unlikely to clog pores. This makes it a suitable option for individuals prone to acne, blemishes, or breakouts.
