Article last updated: October 15, 2024
Diethyl Ketoglutarate, often abbreviated as DEKG, is an organic compound that conforms to the chemical formula C9H14O5. This ingredient is also known by other names such as Diethyl 2-oxoglutarate and Diethyl oxoglutarate. It is a derivative of alpha-ketoglutaric acid, which is a key intermediate in the Krebs cycle, a crucial metabolic pathway in cellular respiration.
The use of Diethyl Ketoglutarate in cosmetics has a relatively recent history. Initially, it was primarily studied for its potential benefits in medical and biochemical applications. Over time, researchers discovered its skin conditioning and skin protecting properties, leading to its incorporation into various skincare formulations. Its ability to enhance the skin’s overall appearance and provide a protective barrier against environmental stressors made it a valuable addition to the cosmetic industry.
Diethyl Ketoglutarate is synthesized through a chemical process that involves the esterification of alpha-ketoglutaric acid with ethanol. This reaction results in the formation of the diethyl ester, which is then purified and prepared for use in cosmetic products. The production process ensures that the final ingredient is of high purity and suitable for application on the skin.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Diethyl Ketoglutarate:
Diethyl Ketoglutarate is known for its skin conditioning properties. This means it helps to maintain the skin in good condition. When used in cosmetic formulations, it can enhance the appearance of dry or damaged skin by reducing flaking and restoring suppleness. Essentially, it acts as a moisturizer, making your skin feel smoother and more hydrated.
Another significant benefit of Diethyl Ketoglutarate is its ability to protect the skin. This function helps to shield the skin from various environmental factors that can cause damage, such as pollution and harsh weather conditions. By forming a protective barrier on the skin’s surface, it helps to prevent moisture loss and keeps the skin looking healthy and vibrant.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Diethyl Ketoglutarate is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Diethyl Ketoglutarate during pregnancy and breastfeeding are lacking. Therefore, it is advisable to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Diethyl Ketoglutarate are generally uncommon. However, it is always recommended to perform a patch test before widespread usage to ensure that your skin does not react adversely to the ingredient.
Diethyl Ketoglutarate has a comedogenic rating of 1, which means it is very unlikely to clog pores. This makes it suitable for individuals who are prone to acne, blemishes, or breakouts.
