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Cis-3-Hexenyl 2-Methylbutyrate: An In-Depth Look at Its Role in Cosmetics

Article last updated: June 13, 2024

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Ever wondered what gives your favorite beauty products their irresistible, fresh scent? Dive into the world of Cis-3-Hexenyl 2-Methylbutyrate and discover its fascinating journey from lab to luxury, along with its myriad benefits and potential side effects.

What is Cis-3-Hexenyl 2-Methylbutyrate?

Cis-3-Hexenyl 2-Methylbutyrate, also known as (Z)-Hex-3-enyl 2-methylbutyrate, is a chemical compound primarily used in the cosmetic industry for its perfuming properties. This ingredient is derived from natural sources such as plants, where it contributes to the characteristic fresh, green, and fruity aroma. Its chemical composition includes a hexenyl group attached to a methylbutyrate moiety, which gives it its distinctive scent profile.

The history of Cis-3-Hexenyl 2-Methylbutyrate in cosmetics dates back to the exploration of natural fragrances and essential oils. As the demand for more natural and appealing scents in personal care products grew, chemists began isolating and synthesizing specific compounds that could replicate these desirable aromas. This particular ingredient gained popularity due to its ability to evoke the fresh scent of cut grass or green leaves, making it a favorite in formulating perfumes, lotions, and other fragranced products.

The production of Cis-3-Hexenyl 2-Methylbutyrate typically involves the esterification process, where hexenol reacts with methylbutyric acid in the presence of a catalyst. This method ensures a high purity of the final product, which is essential for maintaining the quality and consistency of the fragrance in cosmetic formulations.

The Benefits/Uses of Cis-3-Hexenyl 2-Methylbutyrate

In this section, we will delve into the officially recognized cosmetic benefits and uses of Cis-3-Hexenyl 2-Methylbutyrate:


Cis-3-Hexenyl 2-Methylbutyrate is primarily used in cosmetics for its perfuming properties. This means it is added to products to impart a pleasant fragrance. The ingredient has a fresh, green, and fruity aroma, often reminiscent of freshly cut grass or green apples. This makes it a popular choice for enhancing the sensory experience of using a cosmetic product, making it more enjoyable and appealing to the user.

Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Cis-3-Hexenyl 2-Methylbutyrate is generally considered safe for use in cosmetic products, primarily serving as a perfuming agent. However, as with any ingredient, there are potential side effects and considerations to keep in mind.

  • Skin irritation
  • Allergic reactions
  • Contact dermatitis

Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Cis-3-Hexenyl 2-Methylbutyrate during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.

Adverse reactions to Cis-3-Hexenyl 2-Methylbutyrate are relatively uncommon, but they can occur. To minimize the risk of an adverse reaction, it is recommended to perform a patch test before widespread usage.

In terms of comedogenicity, Cis-3-Hexenyl 2-Methylbutyrate scores a 0 on a scale of 0 to 5, indicating that it is non-comedogenic. This means it is unlikely to clog pores or contribute to acne, making it suitable for individuals prone to blemishes and breakouts.

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