Chelidonine: An In-Depth Look at Its Role in Cosmetics

What Is Chelidonine?

Chelidonine, also known by its complex chemical name [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,4-hexahydro-13-methyl-, (5bR,6S,12bS)-, is a naturally occurring alkaloid primarily derived from the plant Chelidonium majus, commonly known as greater celandine. This plant has a long history of use in traditional medicine, particularly in Europe and Asia, where it has been employed for its purported healing properties.

Chelidonine’s journey into the world of cosmetics is relatively recent. Historically, it was studied for its potential medicinal benefits, including anti-inflammatory and analgesic properties. However, as research progressed, scientists discovered that chelidonine could also offer benefits for skin health, leading to its inclusion in various skincare formulations. Its primary function in cosmetics, as recognized by the CosIng Database, is skin conditioning, which means it helps to maintain the skin in good condition, making it a valuable ingredient in moisturizers, serums, and other skincare products.

The extraction and production of chelidonine for cosmetic use involve isolating the compound from the greater celandine plant. This process typically includes harvesting the plant, drying it, and then using solvents to extract the alkaloids. The extracted chelidonine is then purified and tested for quality before being incorporated into cosmetic formulations. This meticulous process ensures that the chelidonine used in skincare products is both effective and safe for consumer use.

The Benefits/Uses of Chelidonine

In this section, we will delve into the officially recognized cosmetic benefits and uses of Chelidonine:

Skin Conditioning

Chelidonine is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. When used in cosmetic products, Chelidonine can help to keep your skin feeling soft, smooth, and hydrated. It works by forming a protective barrier on the skin’s surface, which helps to lock in moisture and prevent dryness. This can be particularly beneficial for individuals with dry or sensitive skin, as it can help to soothe and nourish the skin, making it feel more comfortable and less irritated.

Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Chelidonine, like many cosmetic ingredients, is generally considered safe for topical use. However, it is important to be aware of potential side effects and other considerations to ensure its suitability for your skin type and condition.

• Skin irritation
• Redness
• Allergic reactions

Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Chelidonine during pregnancy are lacking. Therefore, it is advisable to consult a healthcare professional for further advice before using products containing this ingredient.

Adverse reactions to Chelidonine are relatively uncommon, but it is always prudent to conduct a patch test before widespread usage to ensure there are no adverse reactions.

In terms of comedogenicity, Chelidonine scores a 1 on a scale of 0 to 5, where 0 is totally non-comedogenic and 5 is highly comedogenic. This low score indicates that Chelidonine is unlikely to clog pores, making it suitable for individuals prone to acne, blemishes, or breakouts.