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Caryophyllene Oxide: An In-Depth Look at Its Role in Cosmetics

Article last updated: June 13, 2024

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Ever wondered what gives your favorite skincare products their magical touch? Dive into the world of Caryophyllene Oxide and discover its transformative role in cosmetics, from its creation to its myriad benefits and potential side effects.

What Is Caryophyllene Oxide?

Caryophyllene Oxide, also known by its chemical name (1R-(1R*,4R*,6R*,10S*))-4,12,12-Trimethyl-9-methylene-5-oxatricyclo[,6]dodecane, or simply beta-Caryophyllene oxide, is a fascinating ingredient in the world of cosmetics. This compound is a naturally occurring sesquiterpene oxide, which can be found in a variety of essential oils, including clove oil, rosemary oil, and hops. Its distinctive aroma, often described as woody and spicy, makes it a popular choice for perfuming applications in cosmetic products.

Historically, Caryophyllene Oxide has been used in traditional medicine and aromatherapy, thanks to its pleasant scent and potential therapeutic properties. However, it wasn’t until more recent years that it gained traction in the cosmetic industry. The shift towards natural and plant-derived ingredients has paved the way for Caryophyllene Oxide to be recognized and utilized for its aromatic qualities.

The production of Caryophyllene Oxide typically involves the extraction of essential oils from plants that are rich in beta-Caryophyllene. This is followed by an oxidation process, which converts beta-Caryophyllene into Caryophyllene Oxide. This method ensures that the compound retains its natural properties, making it a desirable ingredient for formulators aiming to create products with a natural and appealing fragrance.

The Benefits/Uses of Caryophyllene Oxide

In this section, we will delve into the officially recognized cosmetic benefits and uses of Caryophyllene Oxide:


Caryophyllene Oxide is primarily used in cosmetics for its perfuming properties. This means that it is added to products to impart a pleasant fragrance. The ingredient is known for its woody, spicy aroma, which can enhance the overall sensory experience of using a cosmetic product. Whether it’s a lotion, cream, or shampoo, the inclusion of Caryophyllene Oxide can make the product more appealing by providing a delightful scent that lingers on the skin or hair.

Note: The listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Caryophyllene Oxide is generally considered safe for use in cosmetic products, with a low likelihood of causing adverse reactions. However, as with any ingredient, there are potential side effects to be aware of when applied topically:

  • Skin irritation
  • Allergic reactions
  • Contact dermatitis

Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Caryophyllene Oxide during pregnancy and breastfeeding are lacking. Therefore, it is recommended to consult a healthcare professional for further advice before using products containing this ingredient.

Side effects and adverse reactions from Caryophyllene Oxide are relatively uncommon. Nevertheless, it is advisable to perform a patch test before widespread usage to ensure there is no sensitivity or allergic reaction to the ingredient.

Caryophyllene Oxide has a comedogenic rating of 1, which means it is very unlikely to clog pores. This makes it a suitable option for individuals prone to acne, blemishes, or breakouts.

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