Enjoy free tracked US shipping & free returns on all orders. *Ts&Cs apply

Biotinoyl Pentapeptide-4: An In-Depth Look at Its Role in Cosmetics

Article last updated: June 12, 2024

Table of Contents
Ever wondered what makes your cosmetics so effective? Dive into our in-depth exploration of Biotinoyl Pentapeptide-4, a key ingredient that enhances beauty products, and discover its production, benefits, uses, and potential side effects.

What is Biotinoyl Pentapeptide-4?

Biotinoyl Pentapeptide-4, also known as Biotinyl-GHK, is a cosmetic ingredient that is the result of a reaction between Biotin and Pentapeptide-4. Biotin, also known as Vitamin B7, is a water-soluble vitamin that plays a crucial role in maintaining healthy hair, skin, and nails. On the other hand, Pentapeptide-4 is a synthetic peptide composed of five amino acids. The combination of these two components results in Biotinoyl Pentapeptide-4, a powerful ingredient with multiple benefits for skin and hair care.

The use of Biotinoyl Pentapeptide-4 in cosmetic products is a relatively recent development. The ingredient was first introduced in the early 2000s, and since then, it has gained popularity for its beneficial properties. It is now commonly found in a variety of cosmetic products, including hair growth serums, eyelash growth products, and anti-aging skincare products.

The process of creating Biotinoyl Pentapeptide-4 involves a chemical reaction between Biotin and Pentapeptide-4. This reaction is typically carried out in a laboratory setting, under controlled conditions. The resulting product is a stable, water-soluble compound that can be easily incorporated into various cosmetic formulations.

The Benefits/Uses of Biotinoyl Pentapeptide-4

In this section, we will delve into the officially recognized benefits and uses of Biotinoyl Pentapeptide-4:


One of the key benefits of Biotinoyl Pentapeptide-4 is its anti-sebum function. Sebum is a natural oil produced by our skin. While it’s necessary for skin health, too much of it can lead to oily skin and clogged pores, which can result in acne. Biotinoyl Pentapeptide-4 helps to regulate sebum production, keeping your skin balanced and less prone to breakouts.


Biotinoyl Pentapeptide-4 also serves as an antimicrobial agent. This means it can help to kill or slow down the growth of bacteria and other microorganisms on your skin. This is particularly beneficial for those with acne-prone skin, as it can help to prevent the bacteria that cause acne from spreading.


As an antioxidant, Biotinoyl Pentapeptide-4 helps to protect your skin from damage caused by harmful free radicals. Free radicals are unstable molecules that can damage the skin cells, leading to premature aging. By neutralizing these free radicals, Biotinoyl Pentapeptide-4 can help to maintain your skin’s youthful appearance and prevent signs of aging.

Hair Conditioning

Not just beneficial for your skin, Biotinoyl Pentapeptide-4 also acts as a hair conditioner. It helps to smooth and soften your hair, making it easier to manage and style. Plus, it can help to strengthen your hair, reducing the risk of breakage and split ends.

Skin Protecting

Lastly, Biotinoyl Pentapeptide-4 offers skin protecting benefits. It helps to strengthen the skin’s natural barrier, protecting it from environmental stressors like pollution and UV rays. This can help to keep your skin healthy and radiant, while also preventing damage that can lead to signs of aging.

Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Biotinoyl Pentapeptide-4 is generally considered safe for topical use. However, as with any cosmetic ingredient, it’s important to be aware of its potential side effects and allergenic potential. While it is not known to be a common allergen, individual reactions can vary. Therefore, it’s always a good idea to conduct a patch test before widespread usage.

Potential side effects of Biotinoyl Pentapeptide-4 may include:

  • Redness
  • Itching
  • Skin irritation

Regarding individuals who are pregnant or breastfeeding, there is currently a lack of data on the safety of topical use of Biotinoyl Pentapeptide-4 during pregnancy or while nursing. Therefore, it is recommended to consult a healthcare professional for further advice.

Adverse reactions to Biotinoyl Pentapeptide-4 are not common, but they can occur. As mentioned earlier, it’s always a good idea to conduct a patch test before widespread usage to ensure you do not have an adverse reaction.

On the comedogenicity scale, Biotinoyl Pentapeptide-4 is rated as a 0, meaning it is non-comedogenic. This means it is unlikely to clog pores or cause breakouts, making it suitable for individuals prone to acne, blemishes, or breakouts. However, everyone’s skin is different, and what works well for one person may not work as well for another.

Join our newsletter & get 15% off your first Deascal order.
Enjoy free express shipping & free returns on all orders. *Ts&Cs apply
Trending Products
15% Off
Enter your name & email below to get a 15% off coupon sent to your inbox.
uk.deascal.com is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
This site uses cookies to improve your experience. By continuing to browse, you agree to the use of cookies. Read the Privacy Policy here.