Article last updated: October 15, 2024
Acetyl Sh-Hexapeptide-5 Amide Acetate, often referred to in the cosmetic industry simply as Acetyl Hexapeptide-5, is a synthetic peptide compound. This ingredient is derived from the acetylation of sh-Hexapeptide-5 SP, where the C-terminus of the peptide is modified to form an amide, and it is then converted into its acetate salt form. This modification enhances its stability and efficacy when used in skincare formulations.
Historically, peptides have been studied for their potential in skin care due to their ability to mimic naturally occurring proteins in the skin. Acetyl Sh-Hexapeptide-5 Amide Acetate is one of the newer generations of these peptides, designed to offer targeted benefits for skin conditioning. Its journey into the cosmetic world began with extensive research into how peptides can influence skin health, leading to its adoption in various skincare products aimed at improving skin texture and appearance.
The production of Acetyl Sh-Hexapeptide-5 Amide Acetate involves a series of chemical processes. Initially, the base peptide, sh-Hexapeptide-5, is synthesized through solid-phase peptide synthesis (SPPS). This method allows for the precise assembly of amino acids into the desired peptide sequence. Following this, the peptide undergoes acetylation, where an acetyl group is introduced to enhance its stability and skin compatibility. Finally, the peptide is converted into its acetate salt form, which further improves its solubility and effectiveness in cosmetic formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Acetyl Sh-Hexapeptide-5 Amide Acetate:
Acetyl Sh-Hexapeptide-5 Amide Acetate is primarily known for its skin conditioning properties. This means that it helps to maintain the skin in good condition. In practical terms, this ingredient can help to improve the overall appearance and feel of your skin. It works by enhancing the skin’s natural barrier function, which helps to retain moisture and keep the skin hydrated. This can lead to a smoother, softer, and more supple complexion. Additionally, well-conditioned skin is better equipped to protect itself from environmental stressors, which can contribute to a healthier and more youthful appearance.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Acetyl Sh-Hexapeptide-5 Amide Acetate is generally considered safe for topical application in cosmetic products. However, as with any skincare ingredient, there are potential side effects and considerations to keep in mind:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Acetyl Sh-Hexapeptide-5 Amide Acetate during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from Acetyl Sh-Hexapeptide-5 Amide Acetate are generally uncommon. However, it is always a good practice to conduct a patch test before widespread usage to ensure that your skin does not react negatively to the ingredient.
In terms of comedogenicity, Acetyl Sh-Hexapeptide-5 Amide Acetate has a comedogenic rating of 0, meaning it is considered non-comedogenic. This is beneficial for individuals prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
