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Acetyl Hexamethyl Indan: An In-Depth Look at Its Role in Cosmetics

Article last updated: June 12, 2024

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Ever wondered what gives your favorite perfume its long-lasting scent? Dive into our in-depth analysis of Acetyl Hexamethyl Indan, a key ingredient in cosmetics, and discover its benefits, uses, and potential side effects.

What is Acetyl Hexamethyl Indan?

Acetyl Hexamethyl Indan, also known as 1,1,2,3,3,6-hexamethylindan-5-yl methyl ketone, is a synthetic compound that is primarily used in the cosmetics industry as a fragrance ingredient. This compound is a member of the family of Indans, which are aromatic hydrocarbons. It’s characterized by its unique structure, which includes a six-membered ring fused to a five-membered ring, with various methyl groups attached.

The use of Acetyl Hexamethyl Indan in cosmetics is relatively recent, with its introduction as a fragrance ingredient occurring in the late 20th century. Its unique, musky scent quickly made it a popular choice among manufacturers, and it’s now found in a wide range of products, from perfumes and colognes to soaps and lotions.

Acetyl Hexamethyl Indan is synthesized in a laboratory setting, typically through a process known as Friedel-Crafts acylation. This involves the reaction of an aromatic compound with an acyl chloride in the presence of a strong Lewis acid catalyst. The result is a complex, aromatic ketone that has a distinctive, appealing scent. Despite its synthetic origins, Acetyl Hexamethyl Indan is considered safe for use in cosmetics, and it’s appreciated by consumers for its ability to enhance the overall fragrance profile of a product.

The Benefits/Uses of Acetyl Hexamethyl Indan

In this section, we will delve into the officially recognized benefits and uses of Acetyl Hexamethyl Indan:


Acetyl Hexamethyl Indan is primarily used in cosmetics for its fragrance properties. This means that it is added to products to give them a specific scent. The scent of a product is a key factor in consumer satisfaction, as it can enhance the overall experience of using the product. Acetyl Hexamethyl Indan is known for its warm, rich, and slightly sweet aroma, which can add a luxurious feel to a variety of cosmetic products, from lotions and creams to perfumes and colognes.


Aside from providing a pleasant scent, Acetyl Hexamethyl Indan also serves a perfuming function. This means that it helps to mask the smell of other ingredients that may not be as pleasant. This is particularly useful in products that contain strong-smelling ingredients, such as certain oils or chemicals. By masking these odors, Acetyl Hexamethyl Indan ensures that the final product has a pleasing and consistent scent, making it more enjoyable for consumers to use.

Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).

Potential Side Effects & Other Considerations

Acetyl Hexamethyl Indan, also known as 1,1,2,3,3,6-hexamethylindan-5-yl methyl ketone, is generally considered safe for use in cosmetics. However, like any ingredient, it may not be suitable for everyone and could potentially cause side effects in some individuals. These may include:

  • Redness
  • Itching
  • Burning sensation
  • Skin irritation

Regarding individuals who are pregnant or breastfeeding, there is currently a lack of data regarding the safety of topical application of products containing Acetyl Hexamethyl Indan. Therefore, it is recommended to consult a healthcare professional for further advice.

While adverse reactions to Acetyl Hexamethyl Indan are not common, it is always advisable to perform a patch test before using a product containing this ingredient on a larger area of skin. This can help to identify any potential sensitivity or allergic reaction to the ingredient.

As for its comedogenicity, Acetyl Hexamethyl Indan is rated as 0 on a scale of 0 to 5, meaning it is non-comedogenic. This suggests that it is unlikely to clog pores or contribute to acne breakouts, making it suitable for individuals with acne-prone skin.

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