Article last updated: October 15, 2024
Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is a fusion peptide that combines Hexapeptide-40 with a single chain recombinant human peptide. This unique ingredient is derived from the Nicotiana benthamiana plant, a relative of the tobacco plant, through advanced biotechnological methods. These methods include either a transient expression system or transgenesis, which involves the stable insertion of a human gene copy into the plant’s DNA.
The gene used is synthesized to be identical to the human gene responsible for coding Tissue Inhibitor of Metalloproteinases-2 (TIMP-2), a protein that can contain up to 220 amino acids. The resulting fusion peptide, however, contains 200 amino acids and may feature disulfide bonds and/or glycosylation, ensuring it consists of the proper sequence of the 20 standard amino acids.
The journey of Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 into the world of cosmetics is rooted in the quest for innovative and effective skin conditioning agents. Initially, the use of plant-based recombinant proteins was explored in the pharmaceutical industry for therapeutic purposes. Over time, the potential benefits of these proteins for skin health and rejuvenation were recognized, leading to their incorporation into cosmetic formulations. The production process involves cultivating Nicotiana benthamiana plants and introducing the synthesized human gene into their system. This can be done transiently, where the gene is temporarily expressed, or through stable transgenesis, where the gene is permanently integrated into the plant’s DNA. The plants then produce the desired recombinant peptide, which is subsequently extracted and purified for use in cosmetic products.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40:
One of the primary benefits of Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is its skin conditioning properties. This means that the ingredient helps to maintain the skin in good condition. It can improve the appearance and feel of the skin, making it softer, smoother, and more supple. By enhancing the skin’s overall texture, it can contribute to a healthier and more youthful look.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is generally considered safe for topical application in cosmetic products. However, as with any skincare ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 during pregnancy are lacking. Therefore, it is advisable for pregnant or breastfeeding women to consult a healthcare professional for further advice before using products containing this ingredient.
While adverse reactions to this ingredient are relatively uncommon, it is recommended to perform a patch test before widespread usage to ensure there is no sensitivity or allergic reaction.
In terms of comedogenicity, Nicotiana Benthamiana Sh-Polypeptide-15 Hexapeptide-40 is rated as a 1 on a scale of 0 to 5, where 0 is totally non-comedogenic and 5 is highly comedogenic. This low rating indicates that it is unlikely to clog pores, making it suitable for individuals who are prone to acne, blemishes, or breakouts.
