Article last updated: October 15, 2024
Nicotiana Benthamiana R-(S-Clostridium Botulinum Polypeptide-1 S-Spider Oligopeptide-1 Sh-Oligopeptide-1), often referred to by its more manageable acronym, NB-RSS, is a cutting-edge cosmetic ingredient derived from the Nicotiana benthamiana plant. This ingredient is a single chain recombinant protein, which means it’s a protein created through recombinant DNA technology. Essentially, scientists fuse genes from three different sources: s-Clostridium Botulinum Polypeptide-1, s-Spider Oligopeptide-1, and sh-Oligopeptide-1, to synthesize a new gene. This synthetic gene is then inserted into the DNA of Nicotiana benthamiana, either transiently or permanently, to produce the desired protein.
The protein itself is quite complex, containing up to 548 amino acids, and may feature disulfide bonds and glycosylation, which are types of chemical modifications that can affect the protein’s stability and function. The fusion peptide is composed of the 20 standard amino acids, ensuring it maintains the necessary structure for its intended use.
The journey of NB-RSS into the world of cosmetics is a fascinating one. Initially, the Nicotiana benthamiana plant was primarily used in scientific research due to its susceptibility to viral infections, making it an excellent model organism. However, with advancements in biotechnology, researchers discovered that this plant could be engineered to produce complex proteins, including those with potential cosmetic benefits. The fusion of genes from Clostridium botulinum (the bacterium responsible for botulinum toxin), spider silk proteins, and human oligopeptides resulted in a unique compound with promising skin conditioning properties.
In the cosmetic industry, NB-RSS is celebrated for its ability to condition the skin, making it a valuable addition to various skincare formulations. However, it’s essential to understand what this ingredient can and cannot do, so consumers are well-informed and not misled by marketing claims.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana R-(S-Clostridium Botulinum Polypeptide-1 S-Spider Oligopeptide-1 Sh-Oligopeptide-1):
One of the primary benefits of Nicotiana Benthamiana R-(S-Clostridium Botulinum Polypeptide-1 S-Spider Oligopeptide-1 Sh-Oligopeptide-1) is its ability to condition the skin. This means it helps to maintain the skin in good condition by improving its appearance and texture. When used in cosmetic formulations, this ingredient can help to make the skin feel softer, smoother, and more hydrated. It works by forming a protective barrier on the skin’s surface, which helps to lock in moisture and prevent dryness. This can be particularly beneficial for individuals with dry or rough skin, as it helps to restore a healthy, supple feel.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana R-(S-Clostridium Botulinum Polypeptide-1 S-Spider Oligopeptide-1 Sh-Oligopeptide-1) is generally considered safe for topical application, but as with any cosmetic ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of this particular ingredient during pregnancy are lacking. Therefore, it is advisable for pregnant or breastfeeding women to consult a healthcare professional for further advice before using products containing this ingredient.
Side effects and adverse reactions from this ingredient are generally uncommon. However, it is recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Nicotiana Benthamiana R-(S-Clostridium Botulinum Polypeptide-1 S-Spider Oligopeptide-1 Sh-Oligopeptide-1) has a comedogenic rating of 1, which means it is unlikely to clog pores. This makes it suitable for individuals prone to acne, blemishes, or breakouts.
