Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 is a fascinating fusion peptide derived from the plant Nicotiana benthamiana. This ingredient is a blend of Hexapeptide-40 and a single chain recombinant human peptide. The human peptide is produced by genetically modifying Nicotiana benthamiana to transiently express or stably insert a copy of a human gene into its DNA. This gene is synthesized to be identical to the one that codes for Vascular Endothelial Growth Factor A (VEGF-A), which can contain up to 412 amino acids and may include disulfide bonds and glycosylation.
The journey of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 into the world of cosmetics is quite intriguing. Initially, Nicotiana benthamiana, a relative of the tobacco plant, was primarily used in scientific research due to its susceptibility to viral infections, making it an excellent model for studying plant-pathogen interactions. Over time, scientists discovered its potential for producing complex proteins through genetic modification. By inserting human genes into the plant’s DNA, researchers could produce human-like peptides in a more sustainable and scalable way compared to traditional methods.
The production process involves synthesizing the human gene that codes for VEGF-A and inserting it into the DNA of Nicotiana benthamiana. This can be done either transiently, where the gene is temporarily expressed, or through stable insertion, where the gene becomes a permanent part of the plant’s genome. The plant then produces the desired peptide, which is subsequently extracted and purified for use in cosmetic formulations.
This innovative approach not only provides a sustainable source of complex peptides but also opens up new possibilities for their application in various cosmetic products.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 is primarily known for its hair conditioning properties. This means it helps to improve the texture and appearance of hair, making it feel softer, smoother, and more manageable. When used in hair care products like shampoos, conditioners, and treatments, this ingredient works to nourish and hydrate the hair strands, reducing frizz and enhancing shine. Essentially, it helps to maintain the overall health of your hair, giving it a more vibrant and healthy look.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 is generally considered safe for topical application in cosmetic products. However, as with any ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 during pregnancy and breastfeeding are lacking. Therefore, it is recommended that they consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 are relatively uncommon. However, it is always advisable to perform a patch test before widespread usage to ensure that you do not have a sensitivity or allergy to the ingredient.
In terms of comedogenicity, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-9 is rated as a 0 on a scale of 0 to 5, meaning it is non-comedogenic. This makes it suitable for individuals who are prone to acne, blemishes, or breakouts, as it does not clog pores.
