Article last updated: October 15, 2024
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6, sometimes referred to simply as NBH-40 Sh-Polypeptide-6, is a fascinating ingredient in the world of cosmetics. This compound is a fusion peptide, which means it combines two different peptides: Hexapeptide-40 and a single chain recombinant human peptide. The human peptide part is particularly interesting because it is produced by inserting a copy of a human gene into the DNA of Nicotiana benthamiana, a type of tobacco plant. This gene is synthesized to be identical to the human gene that codes for Interleukin 10, a protein known for its anti-inflammatory properties.
The fusion peptide can contain up to 166 amino acids, which may include disulfide bonds and glycosylation, adding to its stability and functionality. The protein is composed of the 20 standard amino acids, ensuring it mimics natural human proteins closely.
The journey of NBH-40 Sh-Polypeptide-6 into cosmetics is quite remarkable. Initially, the use of Nicotiana benthamiana in biotechnology was primarily for pharmaceutical purposes, such as producing vaccines and therapeutic proteins. However, the cosmetic industry quickly recognized the potential of this technology for creating highly effective skin conditioning agents. Utilizing the plant’s ability to produce human-like peptides, scientists were able to develop a new class of cosmetic ingredients that offer advanced benefits for skin care.
The production process involves either transient expression or stable insertion of the human gene into the Nicotiana benthamiana plant. In transient expression, the gene is temporarily introduced into the plant cells, allowing for rapid production of the peptide. In stable insertion, the gene is permanently integrated into the plant’s genome, enabling continuous production. Once the peptide is produced, it is extracted and purified for use in cosmetic formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6:
Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition, making it feel softer, smoother, and more hydrated. When applied in cosmetic formulations, this ingredient can enhance the overall texture and appearance of the skin, giving it a healthier and more youthful look. It works by interacting with the skin’s natural processes to improve moisture retention and elasticity, which can be particularly beneficial for dry or aging skin.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
When considering the use of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 in cosmetic products, it is important to be aware of its safety, suitability, and allergenic potential. While this ingredient is generally considered safe for topical application, there are some potential side effects to be mindful of:
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 during pregnancy are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to this ingredient are generally uncommon, but as with any cosmetic ingredient, individual responses can vary. It is recommended to perform a patch test before widespread usage to ensure there are no adverse reactions.
In terms of comedogenicity, Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-6 has a rating of 0, meaning it is considered non-comedogenic. This is good news for individuals prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
