Article last updated: October 15, 2024
Acetyl Sh-Tripeptide-1 Amide, also known as Acetyl Tripeptide-1 Amide, is a synthetic peptide derived from the acetylation of Sh-Tripeptide-1, where the C-terminus is modified to form an amide. This ingredient is primarily used in cosmetic products for its skin conditioning properties. Peptides like Acetyl Sh-Tripeptide-1 Amide are short chains of amino acids, which are the building blocks of proteins. In this case, the peptide is composed of three amino acids linked together, with an acetyl group added to enhance its stability and efficacy.
The use of peptides in skincare has a relatively recent history, gaining popularity in the late 20th and early 21st centuries as advancements in biochemistry and dermatology revealed their potential benefits for skin health. Acetyl Sh-Tripeptide-1 Amide emerged as a result of these scientific explorations, offering a targeted approach to skin conditioning by mimicking natural processes in the skin.
The production of Acetyl Sh-Tripeptide-1 Amide involves a series of chemical reactions. Initially, the tripeptide is synthesized through solid-phase peptide synthesis (SPPS), a method that allows for the precise assembly of amino acids in a specific sequence. Once the tripeptide is formed, it undergoes acetylation, a chemical process where an acetyl group is introduced to the molecule. Finally, the C-terminus of the peptide is modified to form an amide, resulting in the final product: Acetyl Sh-Tripeptide-1 Amide. This meticulous process ensures the stability and effectiveness of the peptide when used in cosmetic formulations.
In this section, we will delve into the officially recognized cosmetic benefits and uses of Acetyl Sh-Tripeptide-1 Amide:
Acetyl Sh-Tripeptide-1 Amide is primarily known for its skin conditioning properties. This means it helps to maintain the skin in good condition. In practical terms, this ingredient can help improve the overall appearance and feel of the skin. It works by enhancing the skin’s natural barrier function, which can lead to a smoother, more hydrated complexion. This is particularly beneficial for those with dry or sensitive skin, as it can help to alleviate dryness and irritation.
Note: the listed benefits above are exclusively based on the officially recognized and defined functions of the ingredient, as documented by the International Nomenclature of Cosmetic Ingredients (INCI).
Acetyl Sh-Tripeptide-1 Amide is generally considered safe for topical use in cosmetic products. However, as with any skincare ingredient, there are potential side effects and considerations to keep in mind.
Regarding individuals who are pregnant or breastfeeding, data and research on the topical usage of Acetyl Sh-Tripeptide-1 Amide during pregnancy and breastfeeding are lacking. Therefore, it is advisable for these individuals to consult a healthcare professional for further advice before using products containing this ingredient.
Adverse reactions to Acetyl Sh-Tripeptide-1 Amide are relatively uncommon, but it is always prudent to perform a patch test before widespread usage to ensure that your skin does not react negatively to the ingredient.
In terms of comedogenicity, Acetyl Sh-Tripeptide-1 Amide is rated as a 0 on a scale of 0 to 5, meaning it is non-comedogenic. This makes it a suitable option for individuals who are prone to acne, blemishes, or breakouts, as it is unlikely to clog pores or exacerbate these conditions.
